DIABETES MELLITUS (T2DM)

It is a chronic condition with high blood sugar caused by insulin resistance
and insufficient insulin. It accounts for 90-95% of diabetes cases.


Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by high blood glucose levels due to insulin resistance and relative insulin deficiency. It is the most common form of diabetes, accounting for around 90-95% of all diabetes cases.

The APOE4 allele has been studied extensively in relation to Type 2 Diabetes Mellitus (T2DM). Research indicates that individuals carrying the APOE4 allele may have a higher risk of developing T2DM and an onset at a younger age.

Diabetes Mellitus

The diagnosis of Type 2 Diabetes Mellitus (T2DM) generally involves several tests to measure blood glucose levels. Here are the most common diagnostic tests:

  1. A1C Test: This test measures your average blood glucose levels over the past 2-3 months. An A1C level of 6.5% or higher on two separate tests indicates diabetes.
  2. Fasting Plasma Glucose (FPG) Test: This test measures blood glucose levels after fasting for at least 8 hours. A fasting blood glucose level of 126 mg/dL or higher on two separate tests indicates diabetes.
  3. Oral Glucose Tolerance Test (OGTT): This test involves drinking a sugary liquid and measuring blood glucose levels before and two hours after consumption. A blood glucose level of 200 mg/dL or higher after two hours indicates diabetes.
  4. Random Plasma Glucose Test: This test measures blood glucose levels at any time of the day, regardless of when you last ate. A blood glucose level of 200 mg/dL or higher suggests diabetes, especially if you have symptoms of high blood sugar.
Diabetes Mellitus

Preventing Type 2 Diabetes Mellitus (T2DM) largely revolves around adopting a healthy lifestyle to manage key risk factors. Here are some effective strategies:

  1. Maintain a Healthy Weight: Being overweight is a major risk factor for T2DM. Follow a balanced diet and exercise regularly to achieve and maintain a healthy weight.
  2. Regular Physical Activity: Engage in at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous activity each week. Activities like walking, swimming, or cycling can be beneficial.
  3. Healthy Diet: Focus on a diet rich in whole grains, lean proteins, fruits, vegetables, and healthy fats. Limit the intake of sugary foods and beverages, refined carbs, and unhealthy fats.
  4. Avoid Tobacco: Smoking increases the risk of diabetes and its complications. If you smoke, seek support to quit.
  5. Limit Alcohol Consumption: Drink alcohol in moderation. Excessive alcohol consumption can increase the risk of developing T2DM.
  6. Regular Medical Check-Ups: Regularly monitor your blood glucose levels, especially if you have a family history of diabetes or other risk factors. Early detection can help manage and prevent complications.

All of these strategies could be implemented more quickly if clinicians had access to the tests developed by Biocross in their hospitals. These tests provide a simple method to stratify at-risk patients even before the onset of the first symptoms.