Pipeline
Biocross is developing a series of blood tests for the diagnosis of Alzheimer’s disease with a view to providing neurologists with an integrated diagnostic solution applicable to any disease stage: asymptomatic AD, mild cognitive impairment (MCI), and symptomatic AD.

Biocross is also developing screening technologies for populations with an elevated risk of late-onset AD.

e4Risk®

The e4Risk® is a non-genetic, cost-effective, and highly reliable method to detect the presence of the ApoE4 protein in human blood plasma using high-throughput chemistry analyzers.

This is achieved using a turbidimetry-based assay with excellent performance in the context of the hospital/clinical settings (100% sensitivity and 99% specificity).

CE Marking. The process of obtaining the FDA approval for the e4Risk® is currently ongoing.

*Test based on patent nº EP15382537.7: “Methods for apolipoprotein detection”

e4Quant

The e4Quant is a quantitative test that allows the precise quantification of ApoE4 in human plasma. This technology is based in turbidimetry and can be used as a predictor of Alzheimer’s disease progression, and as an important risk factor for cardiovascular disease (CVD).

For research use only. The process of obtaining the CE marking for the e4Quant is currently ongoing.

*Test based on patent nº EP15382537.7: “Methods for apolipoprotein detection”.

e4Quant Plus

The eQuant Plus is an advance version of e4Quant that allows the precise quantification of ApoE4 in human plasma and to determine the apoe4 status of the patient, distinguishing between homozygous and heterozygous. The technology is based in turbidimetry allowing easy implementation in clinical practice.

The e4Quant Plus t is currently in the IVD development phase, and is expected to be available as a RUO kit by 3Q of 2021.

*Test based on patent nº EP15382537.7: “Methods for apolipoprotein detection”.

AD Dementia test

The AD Dementia test is a multiparametric test that combines the detection and quantification of up to 9 metabolites or proteins in a plasma sample. Input of these measurements into an algorithm provides an accurate diagnosis and classifies the patient as either AD (Alzheimer´s disease), FTD (frontotemporal dementia) or healthy.

The AD Dementia test is currently in the IVD development phase, and is expected to be available as a RUO kit by 3Q of 2022.

Degenerative Dementia test

The Degenerative Dementia (DD) test is based on the detection and quantification of up to 7 biomarkers in the blood that are specifically altered in patients affected by neurodegeneration due to FTD or AD.

The DD test is rapid and cost-effective and may be used as a screening tool to detect early-stage neurodegeneration.

The DD test is currently in the IVD development phase and is expected to be available as a RUO kit by 3Q of 2023.

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